Senior Scientist Phage Display

CK Group are working in partnership with Nxera Pharma UK Limited (formerly Sosei Heptares) to recruit a lab-based Research Scientist/Senior Scientist position in the Protein Binder Discovery team based in Granta Park, Cambridge. Grade commensurate with experience level.Company:Nxera Pharma is a technology powered biopharma company, in pursuit of new specialty medicines to improve the lives of patients with unmet needs in Japan and globally, focused on therapeutic areas in inflammation diseases, neurology and immunology.The Role:We are seeking an experienced phage display scientist to join the Protein Binders team, part of our Platform Technology division at Nxera Pharma. The successful candidate will use phage display expertise to identify protein binders against therapeutic membrane protein targets to enable structure determination and drug discovery efforts. The candidate would work in interdisciplinary teams in a project-centric fashion, aiming to accelerate the development of life-changing medicines.The role will include the following responsibilities:Employing phage display technology to select protein binders against membrane protein targetsScreening and validating hits using high-throughput assays e.g. ELISA formats, BLI, cell binding assaysSubcloning of plasmid constructs for expression and protein engineering of VHH frameworksBiophysical evaluation of VHH hitsSharing your expertise and insights across the team, project and department to help influence project success.Requirements:PhD (or MSc/MRes with equivalent lab experience) in a relevant area of biology with at least 3-years experience carrying out phage display campaignsTheoretical and practical expertise in phage display technologies and selection techniquesExperience working with phage antibody libraries and preferably VHH displayStrong and evidenced molecular biology proficiencyDemonstrable expertise in protein-protein interaction screening techniquesDynamic, analytical thinker with good problem-solving skillsHave strong interpersonal skills and interact effectively with scientists across disciplines to generate timely and informative data.Desirables:Experience of measuring affinity using either BLI or SPRExperience of affinity maturationExperience of library build (either affinity maturation or immunised, naïve or synthetic libraries)Experience in working with membrane proteins (in particular GPCRs)Computational expertise focussed around protein binder design would be highly advantageousApply:Please quote job reference 99230 in all correspondence.