Senior Scientist

Planet Pharma is currently recruiting for a Senior Scientist to work for a leading organisation in London. It is essential you hold the following: Bioconjugation experience is essential - Lysine, inter-chain cysteine, site specific cysteine etc. Nice to have but not essential (NTHVNE) - ADC experience NTHVNE - Protein purification, Analytical Characterisation HPLC etc. SEC, RP, HIC, LCMS Either PHD with industry experience of BSc/MSc with more industry experience. Responsibilities • Independently design, produce, and characterise ADCs using standard and state-of-the-art methods, aligning with QC criteria. • Lead and carrying out laboratory experiments focused on ADC conjugation, purification, and analytical characterisation, leveraging expertise in bioconjugation and protein engineering. • Establish early discovery stage bioconjugation capability, focusing on bioconjugation, purification, and analytical characterisation of ADC for in vitro cytotoxicity and POC in vivo studies • Lead project teams through discovery and preclinicalstages, coordinating efforts to meet key milestones and drive projects forward effectively. • Oversee outsourced ADC process development, managing relationships to ensure successful GLP/GMP manufacturing and timely IND submissions. Requirements PhD with 3+ years of industry experience, or BSc/MSc with 4-6+ years of relevant industry experience. • In-depth understanding of bioconjugation chemistries, including lysine, inter-chain cysteine, sitespecific cysteine, and others. • Proven expertise in developing purification strategies using a variety of chromatographic techniques such as affinity, size exclusion, ion-exchange, hydrophobic interaction, and tangential flow filtration. • Skilled in the analytical characterisation of ADCs, with experience in techniques like SEC-HPLC, RPHPLC, HIC-HPLC, LC-MS, CE-SDS, ELISA, DSC, and BLI/SPR. • Comprehensive knowledge of all aspects of ADC design, production, and characterisation, along with direct experience in IND filing requirements for ADCs. • Extensive expertise in key areas such as analytical characterisation, formulation, and the overall CMC scope of ADCs and biologics. • Exceptional problem-solving skills and the ability to make data-driven decisions. • Ability and desire to contribute in fast paced, goal-oriented environment. • Highly adaptable, strong problem solver, with the ability to innovate and work collaboratively.